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CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury
BACKGROUND & AIMS: The severity of sepsis can be linked to excessive inflammatory responses resulting in hepatic injury. P2X7 receptor activation by extracellular ATP (eATP) exacerbates inflammation by augmenting cytokine production; while CD39 (ENTPD1) scavenges eATP to generate adenosine, ther...
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Publicado no: | J Hepatol |
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Main Authors: | , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5875702/ https://ncbi.nlm.nih.gov/pubmed/28554875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2017.05.021 |
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