Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy

Human GWAS and Mendelian genetic studies have linked polymorphic variants and mutations in the human uromodulin gene (UMOD) with chronic kidney disease. The primary function of this kidney‐specific and secreted protein remains elusive. This study investigated whether UMOD deficiency modified respons...

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Bibliografski detalji
Izdano u:Physiol Rep
Glavni autori: Maydan, Olena, McDade, Paul G., Liu, Yan, Wu, Xue‐Ru, Matsell, Douglas G., Eddy, Allison A.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875544/
https://ncbi.nlm.nih.gov/pubmed/29595914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13654
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