Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state

Signal regulatory protein α (SIRPα), an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, is an essential negative regulator of leukocyte inflammatory responses. Here we report that SIRPα cytoplasmic signalling ITIMs in neutrophils are cleaved during active inflammation and...

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Publicado en:Nat Commun
Main Authors: Zen, Ke, Guo, Yalan, Bian, Zhen, Lv, Zhiyuan, Zhu, Dihan, Ohnishi, Hiroshi, Matozaki, Takashi, Liu, Yuan
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875419/
https://ncbi.nlm.nih.gov/pubmed/24026300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3436
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