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Loss of cell surface CD47 ‘clustering’ formation and binding avidity to SIRPα facilitate apoptotic cell clearance by macrophage

CD47, a ‘self’ recognition marker expressed on tissue cells, interacts with immunoreceptor SIRPα expressed on the surface of macrophages to initiate inhibitory signaling that prevents macrophage phagocytosis of healthy host cells. Previous studies have suggested that cells may lose the surface CD47...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Lv, Zhiyuan, Bian, Zhen, Shi, Lei, Niu, Shuo, Ha, Bin, Tremblay, Alexandra, Li, Liangwei, Zhang, Xiugen, Paluszynski, John, Liu, Ming, Zen, Ke, Liu, Yuan
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490976/
https://ncbi.nlm.nih.gov/pubmed/26085683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401719
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