Loss of cell surface CD47 ‘clustering’ formation and binding avidity to SIRPα facilitate apoptotic cell clearance by macrophage

CD47, a ‘self’ recognition marker expressed on tissue cells, interacts with immunoreceptor SIRPα expressed on the surface of macrophages to initiate inhibitory signaling that prevents macrophage phagocytosis of healthy host cells. Previous studies have suggested that cells may lose the surface CD47...

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Publicado no:J Immunol
Main Authors: Lv, Zhiyuan, Bian, Zhen, Shi, Lei, Niu, Shuo, Ha, Bin, Tremblay, Alexandra, Li, Liangwei, Zhang, Xiugen, Paluszynski, John, Liu, Ming, Zen, Ke, Liu, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490976/
https://ncbi.nlm.nih.gov/pubmed/26085683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401719
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