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Loss of cell surface CD47 ‘clustering’ formation and binding avidity to SIRPα facilitate apoptotic cell clearance by macrophage
CD47, a ‘self’ recognition marker expressed on tissue cells, interacts with immunoreceptor SIRPα expressed on the surface of macrophages to initiate inhibitory signaling that prevents macrophage phagocytosis of healthy host cells. Previous studies have suggested that cells may lose the surface CD47...
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| Foilsithe in: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490976/ https://ncbi.nlm.nih.gov/pubmed/26085683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401719 |
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