Suppression of type I IFN signaling in tumors mediates resistance to anti-PD-1 treatment that can be overcome by radiotherapy

Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistanc...

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Pubblicato in:Cancer Res
Autori principali: Wang, Xiaohong, Schoenhals, Jonathan E, Li, Ailin, Valdecanas, David R, Ye, Huiping, Zhang, Fenglin, Tang, Chad, Krishnan, Sunil, Allison, James, Sharma, Padmanee, Hwu, Patrick, Komaki, Ritsuko, Overwijk, Willem, Gomez, Daniel R., Chang, Joe Y., Hahn, Stephen M., Cortez, Maria Angelica, Welsh, James W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875182/
https://ncbi.nlm.nih.gov/pubmed/27821490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3142
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