The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

BACKGROUND: Currently, several amyloid beta (Aβ) antibodies, including the protofibril selective antibody BAN2401, are in clinical trials. The murine version of BAN2401, mAb158, has previously been shown to lower the levels of pathogenic Aβ and prevent Aβ deposition in animal models of Alzheimer’s d...

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Foilsithe in:J Neuroinflammation
Main Authors: Söllvander, Sofia, Nikitidou, Elisabeth, Gallasch, Linn, Zyśk, Marlena, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875007/
https://ncbi.nlm.nih.gov/pubmed/29592816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1134-4
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