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VHL and Hypoxia Signaling: Beyond HIF in Cancer
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 ligase, which targets hypoxia inducible factor α (including HIF1α and HIF2α) for proteasome degradation. In recent...
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| Izdano u: | Biomedicines |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5874692/ https://ncbi.nlm.nih.gov/pubmed/29562667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines6010035 |
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