The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity

The paramyxovirus replication machinery comprises the viral large (L) protein and phosphoprotein (P-protein) in addition to the nucleocapsid (N) protein, which encapsidates the single-stranded RNA genome. Common to paramyxovirus N proteins is a C-terminal tail (Ntail). The mechanistic role and relev...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Thakkar, Vidhi D., Cox, Robert M., Sawatsky, Bevan, da Fontoura Budaszewski, Renata, Sourimant, Julien, Wabbel, Katrin, Makhsous, Negar, Greninger, Alexander L., von Messling, Veronika, Plemper, Richard K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874420/
https://ncbi.nlm.nih.gov/pubmed/29437959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02064-17
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