Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

Genome-wide association studies (GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Carey, Heather A., Hildreth, Blake E., Geisler, Jennifer A., Nickel, Mara C., Cabrera, Jennifer, Ghosh, Sankha, Jiang, Yue, Yan, Jing, Lee, James, Makam, Sandeep, Young, Nicholas A., Valiente, Giancarlo R., Jarjour, Wael N., Huang, Kun, Rosol, Thomas J., Toribio, Ramiro E., Charles, Julia F., Ostrowski, Michael C., Sharma, Sudarshana M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874256/
https://ncbi.nlm.nih.gov/pubmed/29619268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-018-0011-1
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