Growth Differentiation Factor-6 Attenuated Pro-inflammatory Molecular Changes in the Rabbit Anular-puncture Model and Degenerated Disc-induced Pain Generation in the Rat Xenograft Radiculopathy Model

PURPOSE: To elucidate the effects of growth differentiation factor-6 (GDF6) on: (i) gene expression of inflammatory/pain-related molecules and structural integrity in the rabbit intervertebral disc (IVD) degeneration model, and (ii) sensory dysfunction and changes in pain-marker expression in dorsal...

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Veröffentlicht in:Eur Spine J
Hauptverfasser: Miyazaki, Shingo, Diwan, Ashish D., Kato, Kenji, Cheng, Kevin, Bae, Won C., Sun, Yang, Yamada, Junichi, Muehleman, Carol, Lenz, Mary E, Inoue, Nozomu, Sah, Robert L, Kawakami, Mamoru, Masuda, Koichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874179/
https://ncbi.nlm.nih.gov/pubmed/29460012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00586-018-5488-1
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