Islet-reactive CD8(+) T-cell frequencies in the pancreas but not blood distinguish type 1 diabetes from healthy donors

The human leukocyte antigen (HLA)-A2-restricted zinc transporter (ZnT)8(186–194) and other islet epitopes elicit interferon-γ secretion by CD8(+) T cells preferentially in type 1 diabetes (T1D) patients compared with controls. Here, we show that clonal ZnT8(186–194)-reactive CD8(+) T cells express p...

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Publicado no:Sci Immunol
Main Authors: Culina, Slobodan, Lalanne, Ana Ines, Afonso, Georgia, Cerosaletti, Karen, Pinto, Sheena, Sebastiani, Guido, Kuranda, Klaudia, Nigi, Laura, Eugster, Anne, Østerbye, Thomas, Maugein, Alicia, McLaren, James E., Ladell, Kristin, Larger, Etienne, Beressi, Jean-Paul, Lissina, Anna, Appay, Victor, Davidson, Howard W., Buus, Søren, Price, David A., Kuhn, Matthias, Bonifacio, Ezio, Battaglia, Manuela, Caillat-Zucman, Sophie, Dotta, Francesco, Scharfmann, Raphael, Kyewski, Bruno, Mallone, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874133/
https://ncbi.nlm.nih.gov/pubmed/29429978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aao4013
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