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Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells

The tumor suppressor gene p53 is frequently mutated in human breast cancer and is a marker for poor prognosis and resistance to chemotherapy. Transplantation of p53 null mouse mammary epithelium into syngeneic wild-type mice leads to normal mammary gland development followed by spontaneous mammary t...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Palaniappan, Murugesan, Edwards, David, Creighton, Chad J., Medina, Daniel, Conneely, Orla M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874056/
https://ncbi.nlm.nih.gov/pubmed/29590203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194913
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