The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

α2δ-1, commonly known as a voltage-activated Ca(2+) channel subunit, is a binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is unclear how α2δ-1 contributes to neuropathic pain and gabapentinoid actions. Here, we show that Cacna2d1 overexpression potentiates pre...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Chen, Jinjun, Li, Lingyong, Chen, Shao-Rui, Chen, Hong, Xie, Jing-Dun, Sirrieh, Rita E., MacLean, David M., Zhang, Yuhao, Zhou, Meng-Hua, Jayaraman, Vasanthi, Pan, Hui-Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873963/
https://ncbi.nlm.nih.gov/pubmed/29490268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.021
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