COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors

Aberrant activation of MAPK signaling leads to the activation of oncogenic transcriptomes. How MAPK signaling is coupled with the transcriptional response in cancer is not fully understood. In 2 MAPK-activated tumor types, gastrointestinal stromal tumor and melanoma, we found that ETV1 and other Pea...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Xie, Yuanyuan, Cao, Zhen, Wong, Elissa W.P., Guan, Youxin, Ma, Wenfu, Zhang, Jenny Q., Walczak, Edward G., Murphy, Devan, Ran, Leili, Sirota, Inna, Wang, Shangqian, Shukla, Shipra, Gao, Dong, Knott, Simon R.V., Chang, Kenneth, Leu, Justin, Wongvipat, John, Antonescu, Cristina R., Hannon, Gregory, Chi, Ping, Chen, Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873878/
https://ncbi.nlm.nih.gov/pubmed/29360641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94840
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