COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors

Aberrant activation of MAPK signaling leads to the activation of oncogenic transcriptomes. How MAPK signaling is coupled with the transcriptional response in cancer is not fully understood. In 2 MAPK-activated tumor types, gastrointestinal stromal tumor and melanoma, we found that ETV1 and other Pea...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xie, Yuanyuan, Cao, Zhen, Wong, Elissa W.P., Guan, Youxin, Ma, Wenfu, Zhang, Jenny Q., Walczak, Edward G., Murphy, Devan, Ran, Leili, Sirota, Inna, Wang, Shangqian, Shukla, Shipra, Gao, Dong, Knott, Simon R.V., Chang, Kenneth, Leu, Justin, Wongvipat, John, Antonescu, Cristina R., Hannon, Gregory, Chi, Ping, Chen, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873878/
https://ncbi.nlm.nih.gov/pubmed/29360641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94840
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