Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. We use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals chronically infected with HCV, pre...

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Udgivet i:Nat Genet
Main Authors: Ansari, M. Azim, Pedergnana, Vincent, Ip, Camilla, Magri, Andrea, Von Delft, Annette, Bonsall, David, Chaturvedi, Nimisha, Bartha, Istvan, Smith, David, Nicholson, George, McVean, Gilean, Trebes, Amy, Piazza, Paolo, Fellay, Jacques, Cooke, Graham, Foster, Graham R, Hudson, Emma, McLauchlan, John, Simmonds, Peter, Bowden, Rory, Klenerman, Paul, Barnes, Eleanor, Spencer, Chris C. A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873514/
https://ncbi.nlm.nih.gov/pubmed/28394351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3835
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