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Single nucleotide editing without DNA cleavage using CRISPR/Cas9-deaminase in the sea urchin embryo
BACKGROUND: A single base pair mutation in the genome can result in many congenital disorders in humans. The recent gene editing approach using CRISPR/Cas9 has rapidly become a powerful tool to replicate or repair such mutations in the genome. These approaches rely on cleaving DNA, while presenting...
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| Publicado no: | Dev Dyn |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5872153/ https://ncbi.nlm.nih.gov/pubmed/28857338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24586 |
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