Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease

Aggregated forms of α-synuclein play a crucial role in the pathogenesis of synucleinopathies such as Parkinson’s disease (PD). However, the molecular mechanisms underlying the pathogenic effects of α-synuclein are not completely understood. Here we show that asparagine endopeptidase (AEP) cleaves hu...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Zhang, Zhentao, Kang, Seong Su, Liu, Xia, Ahn, Eun Hee, Zhang, Zhaohui, He, Li, Iuvone, P Michael, Duong, Duc M, Seyfried, Nicholas T, Benskey, Matthew J, Manfredsson, Fredric P, Jin, Lingjing, Sun, Yi E, Wang, Jian-Zhi, Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871868/
https://ncbi.nlm.nih.gov/pubmed/28671665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3433
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