MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

Trithorax group protein MLL5 is an important epigenetic modifier that controls cell cycle progression, chromatin architecture maintenance, and hematopoiesis. However, whether MLL5 has a role in innate antiviral immunity is largely unknown. Here we show that MLL5 suppresses the RIG-I-mediated anti-vi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zhou, Peipei, Ding, Xiaodan, Wan, Xiaoling, Liu, Lulu, Yuan, Xiujie, Zhang, Wei, Hui, Xinhui, Meng, Guangxun, Xiao, Hui, Li, Bin, Zhong, Jin, Hou, Fajian, Deng, Lihwen, Zhang, Yan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871759/
https://ncbi.nlm.nih.gov/pubmed/29593341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03563-8
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