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Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart

Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactiv...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Whitehead, Natasha, Gill, Jonathan F., Brink, Marijke, Handschin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871735/
https://ncbi.nlm.nih.gov/pubmed/29618980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00242
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