Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems...

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Published in:Cell
Main Authors: Savitski, Mikhail M., Zinn, Nico, Faelth-Savitski, Maria, Poeckel, Daniel, Gade, Stephan, Becher, Isabelle, Muelbaier, Marcel, Wagner, Anne J., Strohmer, Katrin, Werner, Thilo, Melchert, Stephanie, Petretich, Massimo, Rutkowska, Anna, Vappiani, Johanna, Franken, Holger, Steidel, Michael, Sweetman, Gavain M., Gilan, Omer, Lam, Enid Y.N., Dawson, Mark A., Prinjha, Rab K., Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus
Format: Artigo
Language:Inglês
Published: Cell Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871718/
https://ncbi.nlm.nih.gov/pubmed/29551266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.030
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