FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis

BACKGROUND: The liver is a vital target for sepsis-related injury, leading to inflammatory pathogenesis, multiple organ dysfunction and high mortality rates. Monocyte-derived macrophage transformations are key events in hepatic inflammation. N(1)-[(4-methoxy)methyl]-4-methyl-1,2-benzenediamine (FC-9...

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Pubblicato in:Oncotarget
Autori principali: Zhao, Yarong, Zhu, Haiyan, Wang, Haining, Ding, Liang, Xu, Lizhi, Chen, Dai, Shen, Sunan, Hou, Yayi, Dou, Huan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871089/
https://ncbi.nlm.nih.gov/pubmed/29599918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24127
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