A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis

BACKGROUND AND PURPOSE: Sepsis is a clinical condition characterized by overwhelming systemic inflammation with high mortality rate and high prevalence, but effective treatment is still lacking. Toll-like receptor 3 (TLR3) is an endogenous sensor, thought to regulate the amplification of immune resp...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Gong, Wei, Hu, Erling, Dou, Huan, Song, Yuxian, Yang, Liu, Ji, Jianjian, Li, Erguang, Tan, Renxiang, Hou, Yayi
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294110/
https://ncbi.nlm.nih.gov/pubmed/24903157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12797
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