Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

Ovarian cancers often recur and tumors acquire resistance to chemotherapy due to overexpression of the ATP-dependent efflux pump, multidrug resistance protein 1 (MDR1/P-glycoprotein/ABCB1). Nontoxic small molecule inhibitors targeting MDR1 have remained largely elusive. Instead, in a novel applicati...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zheng, Xiaobin, Andruska, Neal, Lambrecht, Michael J., He, Sisi, Parissenti, Amadeo, Hergenrother, Paul J., Nelson, Erik R., Shapiro, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871075/
https://ncbi.nlm.nih.gov/pubmed/29599904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10819
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