Long-term delivery of brain-derived neurotrophic factor (BDNF) from nanoporous silica nanoparticles improves the survival of spiral ganglion neurons in vitro

Sensorineural hearing loss (SNHL) can be overcome by electrical stimulation of spiral ganglion neurons (SGNs) via a cochlear implant (CI). Restricted CI performance results from the spatial gap between the SGNs and the electrode, but the efficacy of CI is also limited by the degeneration of SGNs as...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schmidt, Nadeschda, Schulze, Jennifer, Warwas, Dawid P., Ehlert, Nina, Lenarz, Thomas, Warnecke, Athanasia, Behrens, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870973/
https://ncbi.nlm.nih.gov/pubmed/29584754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194778
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