Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer

Pyridoxine 5′-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5′-phosphate into pyridoxal 5′-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In t...

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Publicado no:Cell Death Dis
Main Authors: Zhang, Lingyun, Zhou, Daibing, Guan, Wencai, Ren, Weimin, Sun, Wenwen, Shi, Jimin, Lin, Qunbo, Zhang, Jinguo, Qiao, Tiankui, Ye, Yulong, Wu, Yun, Zhang, Yaning, Zuo, Xulei, Connor, Kristin L, Xu, Guoxiong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870590/
https://ncbi.nlm.nih.gov/pubmed/29238081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0050-3
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