Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer

Pyridoxine 5′-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5′-phosphate into pyridoxal 5′-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In t...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Zhang, Lingyun, Zhou, Daibing, Guan, Wencai, Ren, Weimin, Sun, Wenwen, Shi, Jimin, Lin, Qunbo, Zhang, Jinguo, Qiao, Tiankui, Ye, Yulong, Wu, Yun, Zhang, Yaning, Zuo, Xulei, Connor, Kristin L, Xu, Guoxiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870590/
https://ncbi.nlm.nih.gov/pubmed/29238081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0050-3
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