CATS (Coordinates of Atoms by Taylor Series): protein design with backbone flexibility in all locally feasible directions

MOTIVATION: When proteins mutate or bind to ligands, their backbones often move significantly, especially in loop regions. Computational protein design algorithms must model these motions in order to accurately optimize protein stability and binding affinity. However, methods for backbone conformati...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Bioinformatics
المؤلفون الرئيسيون: Hallen, Mark A, Donald, Bruce R
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2017
الموضوعات:
Ismb/Eccb 2017: The 25th Annual Conference Intelligent Systems for Molecular Biology Held Jointly with the 16th Annual European Conference on Computational Biology, Prague, Czech Republic, July 21–25, 2017
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870559/
https://ncbi.nlm.nih.gov/pubmed/28882005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx277
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