HopLand: single-cell pseudotime recovery using continuous Hopfield network-based modeling of Waddington’s epigenetic landscape

MOTIVATION: The interpretation of transcriptional dynamics in single-cell data, especially pseudotime estimation, could help understand the transition of gene expression profiles. The recovery of pseudotime increases the temporal resolution of single-cell transcriptional data, but is challenging due...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Guo, Jing, Zheng, Jie
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Ismb/Eccb 2017: The 25th Annual Conference Intelligent Systems for Molecular Biology Held Jointly with the 16th Annual European Conference on Computational Biology, Prague, Czech Republic, July 21–25, 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870541/
https://ncbi.nlm.nih.gov/pubmed/28881967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx232
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