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High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice

BACKGROUND: Elevated plasma levels of angiopoietin-2 (ANGPT2) have been reported in patients with acute lung injury (ALI); however, it remains unclear whether this increase contributes to, or just marks, the underlying vasculopathic inflammation and leak associated with ALI. Here we investigated the...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Schlosser, Kenny, Taha, Mohamad, Deng, Yupu, McIntyre, Lauralyn A, Mei, Shirley H J, Stewart, Duncan J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870448/
https://ncbi.nlm.nih.gov/pubmed/28947667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2017-210413
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