Genome-wide analysis of PDX1 target genes in human pancreatic progenitors

OBJECTIVE: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical mod...

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Publicado en:Mol Metab
Autores principales: Wang, Xianming, Sterr, Michael, Burtscher, Ingo, Chen, Shen, Hieronimus, Anja, Machicao, Fausto, Staiger, Harald, Häring, Hans-Ulrich, Lederer, Gabriele, Meitinger, Thomas, Cernilogar, Filippo M., Schotta, Gunnar, Irmler, Martin, Beckers, Johannes, Hrabě de Angelis, Martin, Ray, Michael, Wright, Christopher V.E., Bakhti, Mostafa, Lickert, Heiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870105/
https://ncbi.nlm.nih.gov/pubmed/29396371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.011
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