Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

OBJECTIVE: The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Metab
Prif Awduron: Bastidas-Ponce, Aimée, Roscioni, Sara S., Burtscher, Ingo, Bader, Erik, Sterr, Michael, Bakhti, Mostafa, Lickert, Heiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444078/
https://ncbi.nlm.nih.gov/pubmed/28580283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.03.007
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