Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

OBJECTIVE: The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susc...

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Publicado en:Mol Metab
Autores principales: Bastidas-Ponce, Aimée, Roscioni, Sara S., Burtscher, Ingo, Bader, Erik, Sterr, Michael, Bakhti, Mostafa, Lickert, Heiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444078/
https://ncbi.nlm.nih.gov/pubmed/28580283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.03.007
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