A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: Implications for the design of agonists and antagonists

In view of the observation that corticotropin-releasing factor (CRF) affects several brain functions through at least two subtypes of G protein-dependent receptors and a binding protein (CRFBP), we have developed synthetic strategies to provide enhanced binding specificity. Human/rat CRF (h/rCRF) an...

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Bibliographische Detailangaben
Hauptverfasser: Eckart, Klaus, Jahn, Olaf, Radulovic, Jelena, Tezval, Hossein, van Werven, Lars, Spiess, Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58697/
https://ncbi.nlm.nih.gov/pubmed/11572971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211424998
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