Proteomic and bioinformatic pipeline to screen the ligands of S. pneumoniae interacting with human brain microvascular endothelial cells

The mechanisms by which Streptococcus pneumoniae penetrates the blood-brain barrier (BBB), reach the CNS and causes meningitis are not fully understood. Adhesion of bacterial cells on the brain microvascular endothelial cells (BMECs), mediated through protein-protein interactions, is one of the cruc...

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Vydáno v:Sci Rep
Hlavní autoři: Jiménez-Munguía, Irene, Pulzova, Lucia, Kanova, Evelina, Tomeckova, Zuzana, Majerova, Petra, Bhide, Katarina, Comor, Lubos, Sirochmanova, Ivana, Kovac, Andrej, Bhide, Mangesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869694/
https://ncbi.nlm.nih.gov/pubmed/29588455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23485-1
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