Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium

During ontogeny, hematopoietic stem and progenitor cells arise from hemogenic endothelium through an endothelial-to-hematopoietic transition that is strictly dependent on the transcription factor RUNX1. Although it is well established that RUNX1 is essential for the onset of hematopoiesis, little is...

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Опубликовано в: :Development
Главные авторы: Lie-A-Ling, Michael, Marinopoulou, Elli, Lilly, Andrew J., Challinor, Mairi, Patel, Rahima, Lancrin, Christophe, Kouskoff, Valerie, Lacaud, Georges
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2018
Предметы:
Stem Cells and Regeneration
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868988/
https://ncbi.nlm.nih.gov/pubmed/29530939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.149419
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