Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury

Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on musc...

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Publicat a:PLoS One
Autors principals: Phillips, Ean G., Beggs, Luke A., Ye, Fan, Conover, Christine F., Beck, Darren T., Otzel, Dana M., Ghosh, Payal, Bassit, Anna C. F., Borst, Stephen E., Yarrow, Joshua F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868788/
https://ncbi.nlm.nih.gov/pubmed/29579075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194440
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