Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein– chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure
The natural product neocarzinostatin (NCS), a protein–small molecule complex, exhibits potent antiproliferative activity in mammalian cells but has little apparent effect on the growth of the unicellular eukaryotic organism, Saccharomyces cerevisiae. Here, we show by whole-genome transcription profi...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58685/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11562456/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.191340698 |
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