Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161(++)TCR iVα7.2(+) Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Mucosal-associated invariant T (MAIT) cells, defined as CD161(++)TCR iVα7.2(+) T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in...

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Pubblicato in:Front Immunol
Autori principali: Yong, Yean K., Saeidi, Alireza, Tan, Hong Y., Rosmawati, Mohamed, Enström, Philip F., Batran, Rami Al, Vasuki, V., Chattopadhyay, Indranil, Murugesan, Amudhan, Vignesh, Ramachandran, Kamarulzaman, Adeeba, Rajarajeswaran, Jayakumar, Ansari, Abdul W., Vadivelu, Jamuna, Ussher, James E., Velu, Vijayakumar, Larsson, Marie, Shankar, Esaki M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868455/
https://ncbi.nlm.nih.gov/pubmed/29616020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00472
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