Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8(+) T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However,...

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Veröffentlicht in:PLoS One
Hauptverfasser: Saeidi, Alireza, Tien Tien, Vicky L., Al-Batran, Rami, Al-Darraji, Haider A., Tan, Hong Y., Yong, Yean K., Ponnampalavanar, Sasheela, Barathan, Muttiah, Rukumani, Devi V., Ansari, Abdul W., Velu, Vijayakumar, Kamarulzaman, Adeeba, Larsson, Marie, Shankar, Esaki M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403924/
https://ncbi.nlm.nih.gov/pubmed/25894562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124659
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