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Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies

C-Terminal cysteine peptide acids are difficult to access without epimerization of the cysteine α-stereocenter. Diversification of the C-terminus after solid-phase peptide synthesis poses an even greater challenge because of the proclivity of the cysteine α-stereocenter to undergo deprotonation upon...

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Bibliografiska uppgifter
I publikationen:Chem Sci
Huvudupphovsmän: Arbour, Christine A., Kondasinghe, Thilini D., Saraha, Hasina Y., Vorlicek, Teanna L., Stockdill, Jennifer L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Royal Society of Chemistry 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868297/
https://ncbi.nlm.nih.gov/pubmed/29629104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03553e
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