Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides

In order to investigate crystallographically the mechanism of inhibition of cysteine protease by α-methyl-γ,γ-diphenylallenecarboxylic acid ethyl ester 3, a cysteine protease inhibitor having in vivo stability, we synthesized N-(α-methyl-γ,γ-diphenylallenecarbonyl)-l-phenylalanine ethyl ester 4. Rea...

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Bibliografiske detaljer
Main Authors: Takeuchi, Yoshio, Fujiwara, Tomoya, Shimone, Yoshihito, Miyataka, Hideki, Satoh, Toshio, Kirk, Kenneth L., Hori, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607570/
https://ncbi.nlm.nih.gov/pubmed/18951789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.007
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