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Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides
In order to investigate crystallographically the mechanism of inhibition of cysteine protease by α-methyl-γ,γ-diphenylallenecarboxylic acid ethyl ester 3, a cysteine protease inhibitor having in vivo stability, we synthesized N-(α-methyl-γ,γ-diphenylallenecarbonyl)-l-phenylalanine ethyl ester 4. Rea...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2607570/ https://ncbi.nlm.nih.gov/pubmed/18951789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.007 |
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