Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity

Zinc is coreleased with glutamate from excitatory nerve terminals throughout the central nervous system and acutely inhibits N-methyl-d-aspartate (NMDA) receptor activation. Here we report that cultured murine cortical neurons briefly exposed to sublethal concentrations of zinc developed increased i...

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Bibliographic Details
Main Authors: Manzerra, Pat, Behrens, M. Margarita, Canzoniero, Lorella M. T., Wang, Xue Qing, Heidinger, Valérie, Ichinose, Tomomi, Yu, Shan Ping, Choi, Dennis W.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
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Colloquium Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC58682/
https://ncbi.nlm.nih.gov/pubmed/11572968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191353598
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