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Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two (89)Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens
We investigated the effect of shed antigen mesothelin on the tumor uptake of amatuximab, a therapeutic anti-mesothelin mAb clinically tested in mesothelioma patients. The B3 mAb targeting a nonshed antigen was also analyzed for comparison. The mouse model implanted with A431/H9 tumor, which expresse...
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| Publicado no: | Contrast Media Mol Imaging |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5867561/ https://ncbi.nlm.nih.gov/pubmed/29720923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/2461257 |
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