Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced

Nitric oxide (NO)-mediated vasodilation contributes to the rapid rise in muscle blood flow at exercise onset. This occurs via increased cyclic guanosine monophosphate (cGMP), which is catabolized by phosphodiesterase-5 (PDE-5). Whether PDE-5 limits exercise vasodilation onset kinetics is unknown. We...

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Detalhes bibliográficos
Publicado no:J Appl Physiol (1985)
Main Authors: Kellawan, J. Mikhail, Limberg, Jacqueline K., Scruggs, Zachariah M., Nicholson, Wayne T., Schrage, William G., Joyner, Michael J., Curry, Timothy B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867368/
https://ncbi.nlm.nih.gov/pubmed/28982942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00483.2017
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