Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in individuals under age 60 and has no treatment or cure. Because many cases of FTD result from GRN nonsense mutations, an animal model for this type of mutation is highly desirable for understanding pathogenesis and testing...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nguyen, Andrew D., Nguyen, Thi A., Zhang, Jiasheng, Devireddy, Swathi, Zhou, Ping, Karydas, Anna M., Xu, Xialian, Miller, Bruce L., Rigo, Frank, Ferguson, Shawn M., Huang, Eric J., Walther, Tobias C., Farese, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866607/
https://ncbi.nlm.nih.gov/pubmed/29511098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722344115
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