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The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na(+) pump endocrine system

Two prescient 1953 publications set the stage for the elucidation of a novel endocrine system: Schatzmann’s report that cardiotonic steroids (CTSs) are all Na(+) pump inhibitors, and Szent-Gyorgi’s suggestion that there is an endogenous “missing screw” in heart failure that CTSs like digoxin may rep...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Cell Physiol
Hovedforfatter: Blaustein, Mordecai P.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866383/
https://ncbi.nlm.nih.gov/pubmed/28971835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00196.2017
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