Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice

BACKGROUND: Reverse electron transport (RET) driven by the oxidation of succinate has been proposed as the mechanism of accelerated production of reactive oxygen species (ROS) in post-ischemic mitochondria. However, it remains unclear whether upon reperfusion, mitochondria preferentially oxidase suc...

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Publicat a:Pediatr Res
Autors principals: Sahni, Prateek V., Zhang, Jimmy, Sosunov, Sergey, Galkin, Alexander, Niatsetskaya, Zoya, Starkov, Anatoly, Brookes, Paul S., Ten, Vadim S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866163/
https://ncbi.nlm.nih.gov/pubmed/29211056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.277
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