Isoflurane Anesthesia Initiated at the Onset of Reperfusion Attenuates Oxidative and Hypoxic-Ischemic Brain Injury

This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial respiration. This significantly attenuates an oxida...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sosunov, Sergey A., Ameer, Xavier, Niatsetskaya, Zoya V., Utkina-Sosunova, Irina, Ratner, Veniamin I., Ten, Vadim S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370491/
https://ncbi.nlm.nih.gov/pubmed/25799166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120456
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