Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling

BACKGROUND: NEC is a devastating neonatal disease characterized by intestinal necrosis. Hypoxia inducible factor-1α (HIF-1α) plays a critical role in cellular oxygen homeostasis. Here, we hypothesized that prolyl hydroxylase (PHD) inhibition, which stabilizes HIF-1α, protects against NEC by promotin...

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Pubblicato in:Pediatr Res
Autori principali: Bowker, Rakhee M., Yan, Xiaocai, Managlia, Elizabeth, Liu, Shirley X.L., Marek, Catherine, Tan, Xiao-Di, De Plaen, Isabelle G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866158/
https://ncbi.nlm.nih.gov/pubmed/29068435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.219
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